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【复材专家系列10】Design of the Next Generation of Bioresorbable Implants
发布者:InCSI 日期:2019/3/14 浏览次数: 576次

Professor Jingzhe PAN (潘敬哲)


Professor in Mechanics of Materials

Department of Engineering,

University of Leicester

    2019314四) 14:00

    点:曹光彪高科技大楼7楼远望庐

邀请人彭华新教授


Abstract: A Holy Grail for clinical cardiology was to develop a scaffold for balloon treated coronary arteries that resorbed once no longer required. Unfortunately, Abbott announced in Sep 2017 that sale of Absorb BVS, the only bioresorbable coronary scaffold approved in Europe and US, would end. Despite initial enthusiasm by cardiologists and the devices being implanted in many thousands of patients, clinical evidence of high rates of very late scaffold thrombosis (VLST) led to concerns of the physician community and discontinued use. This is a major setback for patients and a new industry built around BVSs. This talk will presents a review of this setback and a computer modelling strategy to address the problem. A mathematical framework for computer simulation of biodegradation of bioresorbable medical implants, such as the coronary stents, is outlined. The mathematical equations can be solved using the finite element method and used for the design of the bioresobable implants. The material parameters in the equations can be obtained through “reverse engineering” of existing devices for which degradation data exit. The data and equations can then be used to predict the degradation rate of new devices that are made of the same polymer. It has been shown that the mathematical model is able to fit all the available degradation data for PLAs and PGA in the literature. A series of demonstration examples are presented here. In particular the model is extended to predicting drug release from degrading polymeric devices as well as change in mechanical properties, such as Young’s modulus, during degradation. The mathematic model offers a powerful tool for the design of the next generation of bioresorbable implants.


报告人简介:

Jingzhe PAN is Professor of Mechanics of Materials in the Department of Engineering, University of Leicester. Prof. Pan is the deputy head of department and head of mechanics of materials research group. The Group hosts an EPSRC Doctor Training Centre on metal processing, a joint Materials Innovation Centre with TWI Ltd and an Advanced Microscopy Centre. He was awarded the 2018 Verulam Medal from the British Institute of Materials, Minerals and Mining (IoM3) in recognition for his distinguished contributions to ceramics.  


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浙大复材专家系列讲座  10

InCSI Special Composites Seminar (No.10)

 

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